This function simulates gene expression data using a spot-based model
Usage
simulate_data(
n,
nct,
effect_range,
intercept_range,
min_effect = 0,
library_size = 500,
spot_ct = min(2, nct),
p = 6,
num_null = 2,
prob_ct = NULL,
family = "poisson",
dispersion = 1
)Arguments
- n
Number of data points
- nct
Number of cell types
- effect_range
Range of effect sizes (effect sizes drawn uniformly on this interval)
- intercept_range
Range for intercepts (intercept sizes drawn uniformly on this interval)
- min_effect
Minimum absolute value of effect sizes.
- library_size
Number of transcripts per cell/spot
- spot_ct
Number of cell types per spot
- p
Number of covariates
- num_null
Number of null coefficients to include
- prob_ct
Optional probabilities for cell type sampling
- family
The data generating distribution. One of poisson, negative binomial,binomial, and gaussian
- dispersion
Dispersion parameter for NB or Gaussian family. Size parameter for NB and sd for Gaussian. Default: 1