Fits a linear model for spatial transcriptomics data using deconvolution and fixed coefficients.
Usage
spot_lm(y, X, lambda, big_X = NULL, fix_coef = NULL, beta_0 = NULL)
Arguments
- y
Response vector.
- X
Covariate matrix (spots × covariates).
- lambda
Deconvolution matrix (spots × cell types).
- big_X
Optional full design matrix (covariates × cell types).
- fix_coef
Logical matrix specifying which coefficients to fix.
- beta_0
Initial coefficients.
Value
A list with:
- beta
Estimated coefficients.
- vcov
Variance-covariance matrix.
- standard_error_matrix
Standard error matrix.
- sigma.sq
Residual variance estimate.